This paper explores the application opportunities, technology requirements and business benefits arising from machine-to- machine (M2M) communication. Intelligent device networking is the next big thing in information technology. It will enable the transition from “dumb” products to smart products as portals into a whole new world of customer value-creation and “smart services.” CDMA-based wireless networks are at the forefront of this transformation. This paper is for the vast community of players that make up the CDMA2000® M2M ecosystem. M2M solution providers, device suppliers, network operators, system integrators, thought leaders in various vertical markets, and investors will benefit from this exploration.